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Noggin Antibody (MA5-41655) in IHC (P)
Immunohistochemistry analysis of Noggin in paraffin-embedded Human Glioma tissue. Samples were incubated with monoclonal antibody (Product # MA5-41655) at a dilution of 30 µg/mL, followed by HRP-Linked Caprine Anti-Mouse IgG using a dilution of 2 µg/mL.
Product Details
MA5-41655
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
A9
Immunogen
Recombinant protein Noggin. The antigen corresponds to amino acid range 28-232 of the target protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2899137
Target Information
Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Noggin; Noggin precursor; symphalangism 1 (proximal)
Gene Aliases: NOG; SYM1; SYNS1; SYNS1A
UniProt ID: (Human) Q13253
Entrez Gene ID: (Human) 9241
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
osteoblast differentiation
in utero embryonic development
endoderm formation
mesoderm formation
epithelial to mesenchymal transition
neural plate morphogenesis
neural tube closure
nervous system development
motor neuron axon guidance
dorsal/ventral pattern formation
spinal cord development
cell differentiation in hindbrain
pituitary gland development
negative regulation of cell migration
BMP signaling pathway
negative regulation of BMP signaling pathway
somatic stem cell population maintenance
wound healing
middle ear morphogenesis
embryonic digit morphogenesis
regulation of neuron differentiation
negative regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
axial mesoderm development
notochord morphogenesis
embryonic skeletal system development
negative regulation of astrocyte differentiation
positive regulation of epithelial cell proliferation
cartilage development
negative regulation of cardiac muscle cell proliferation
limb development
embryonic skeletal joint morphogenesis
negative regulation of cytokine activity
face morphogenesis
negative regulation of pathway-restricted SMAD protein phosphorylation
lung morphogenesis
prostatic bud formation
ureteric bud formation
fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
negative regulation of cartilage development
somite development
negative regulation of canonical Wnt signaling pathway
positive regulation of branching involved in ureteric bud morphogenesis
positive regulation of glomerulus development
regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
negative regulation of apoptotic signaling pathway
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