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Product Details
CF500029
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
OTI1H8
Immunogen
Human recombinant protein fragment corresponding to amino acids 28-232 of human noggin produced in E.coli.
Conjugate
Form
lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Noggin; Noggin precursor; symphalangism 1 (proximal)
Gene Aliases: NOG; SYM1; SYNS1; SYNS1A
UniProt ID: (Human) Q13253
Entrez Gene ID: (Human) 9241
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
osteoblast differentiation
in utero embryonic development
endoderm formation
mesoderm formation
epithelial to mesenchymal transition
neural plate morphogenesis
neural tube closure
nervous system development
motor neuron axon guidance
dorsal/ventral pattern formation
spinal cord development
cell differentiation in hindbrain
pituitary gland development
negative regulation of cell migration
BMP signaling pathway
negative regulation of BMP signaling pathway
somatic stem cell population maintenance
wound healing
middle ear morphogenesis
embryonic digit morphogenesis
regulation of neuron differentiation
negative regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
axial mesoderm development
notochord morphogenesis
embryonic skeletal system development
negative regulation of astrocyte differentiation
positive regulation of epithelial cell proliferation
cartilage development
negative regulation of cardiac muscle cell proliferation
limb development
embryonic skeletal joint morphogenesis
negative regulation of cytokine activity
face morphogenesis
negative regulation of pathway-restricted SMAD protein phosphorylation
lung morphogenesis
prostatic bud formation
ureteric bud formation
fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
negative regulation of cartilage development
somite development
negative regulation of canonical Wnt signaling pathway
positive regulation of branching involved in ureteric bud morphogenesis
positive regulation of glomerulus development
regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
negative regulation of apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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