Suggested positive control: human, mouse or rat brain.
Nogo-B is a novel myelin-associated, intermediate-length splice variant of Nogo belonging to the reticulon family. It is a multidomain neurite growth inhibitory protein containing several discrete regions with growth inhibitory functions and is a component of the CNS myelin that prevents axonal regeneration in the adult vertebrate CNS. Nogo-B along with NGBR mediated chemotaxis in HUVECs and induced tube formation in 3-dimensional cultures. It is mostly found in intact blood vessels, smooth muscle cells, and endothelial cell, with its N terminus oriented extracellularly and is a regulator of vascular homeostasis and remodeling. It plays an important role in sporadic and familial amyotrophic lateral sclerosis
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Foocen; Glut4 vesicle 20 kDa protein; GLUT4 vesicle 20kDa protein; Human NogoA; MGC116054; My043 protein; neurite growth inhibitor 220; Neurite outgrowth inhibitor; Neuroendocrine-specific protein; Neuroendocrine-specific protein C homolog; NI-220/250; NI-250; Nogo protein; NSP; r; rat N; rat NogoA; reticulon 5; Reticulon-4; Reticulon-5; RTN-x; Vp20
Gene Aliases: 1110020G17Rik; AA407876; AA409940; AA960376; ASY; C130026I10Rik; KIAA0886; mKIAA0886; mKIAA4153; My043; Nbla00271; Nbla10545; NgA; NI-250; NI220/250; NOGO; NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; r; rat N; rat NogoA; RTN-X; RTN4; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C; SP1507; Vp20
Molecular Function: membrane traffic protein