|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide: P(125) E L Q T L T R P G A L R A P R R(141)|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-4514 detects splice variants Nop30/ARC of the nucleolar protein Nop30 in human samples.
PA1-4514 has been used successfully in Western blot procedures. By Western blot this antibody detects a ~25 kDa protein representing recombinant Nop30.
The PA1-4514 immunogen corresponds to amino acid residues 125-141 of the 25 kDa human Nop30/ARC protein.
A CARD domain containing protein, designated ARC for apoptosis repressor with CARD, suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1, and DR3. The predominant nucleolar localization of the isoform Nop30 points to a potential role in RNA processing in muscle nucleoli.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.