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Invitrogen
Norepinephrine Transporter Monoclonal Antibody (CL3063)
Product Details
MA5-24647
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
CL3063
Immunogen
Recombinant protein corresponding to Human Norepinephrine Transporter
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2637262
Product Specific Information
Immunogen sequence: SLYYLFSSFT LNLPWTDCGH TWNSPNCTDP KLLNGSVLGN HTKYSKYKFT PAAEFYERGV LHLHESSGIH DI
Binds to an epitope located within the peptide sequence HTKYSKYKFTPAAEF as determined by overlapping synthetic peptides.
Target Information
Norepinephrine Transporter [NET, or noradrenaline transporter (NAT)] is a monoamine transporter that transports the neurotransmitter noradrenaline from the synapse back to its vesicles for storage until later use. It also appears to transport the neurotransmitter dopamine in the same way, but to a lesser degree. Studies have shown a decrease in NET levels in the locus coeruleus in patients diagnosed with major depression. Cocaine, amphetamines and many therapeutic antidepressants, such as the SNRIs (serotonin-norepinephrine reuptake inhibitors) and the tricyclic antidepressants (TCAs) act to raise noradrenaline. Furthermore, deficits in the NET gene have been associated with ADHD.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: NaCl-dependent norepinephrine transporter; NE transporter; NET; neurotransmitter transporter; neurotransmitter transporter, noradrenal; noradrenaline; Norepinephrine transporter; Sodium-dependent noradrenaline transporter; solute carrier family 6 (neurotransmitter transporter), member 2; solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2; Solute carrier family 6 member 2; solute carrier family 6 member 5; transmembrane region 4..26 transmembrane region 55..77 transmembrane region 105..123 transmembrane region 136..157
Gene Aliases: NAT1; NE-T; NET; NET1; SLC6A2; SLC6A5
UniProt ID: (Human) P23975, (Mouse) O55192
Entrez Gene ID: (Human) 6530, (Rat) 83511, (Mouse) 20538
dopamine:sodium symporter activity
norepinephrine:sodium symporter activity
protein binding
monoamine transmembrane transporter activity
metal ion binding
neurotransmitter:sodium symporter activity
norepinephrine transmembrane transporter activity
alpha-tubulin binding
beta-tubulin binding
symporter activity
primary active transporter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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