|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a region within amino acids 2256 and 2321 of Human Notch 3|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
PA5-28082 targets Notch 3 in WB applications and shows reactivity with Human samples.
The PA5-28082 immunogen is synthetic peptide corresponding to a region within amino acids 2256 and 2321 of Human Notch 3.
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
CADASIL; CASIL; neurogenic locus notch homolog protein 3; Notch homolog 3
CADASIL; CADASIL1; CASIL; IMF2; LMNS; NOTCH3