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|Tested species reactivity||Human , Mouse , Rat , Primate , Cattle|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant protein derived from the intracellular domain of mouse Notch1|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Notch1 is a single transmembrane receptor expressed in a range of cells including hematopoietic cells in mouse fetal liver, adult thymus and bone marrow. Notch1 plays a role in embryonic development and tissue homeostasis in the adult. Recent work has suggested a further role for this receptor in the regulation of lymphopoieisis and myelopoiesis. Following ligand binding, Notch1 is cleaved in the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus, where it plays a role in the modulation of gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
9930111A19Rik, hN1, lin-12, Tan1, TAN1, Mis6, NOTCH, N1
Motch A, Notch gene homolog 1, mT14, major type A protein, neurogenic locus notch homolog protein 1, p300, transmembrane receptor Notch1, Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila), Notch homolog 1, translocation-associated, translocation-associated notch protein TAN-1, RP23-306D20.12-001, 9930111A19Rik, Mis6, N1, Tan1, lin-12