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|Tested species reactivity||Mouse|
|Host / Isotype||Armenian hamster / IgG|
|Immunogen||mouse notch 3 protein|
|Storage buffer||proprietary buffer|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CADASIL; CASIL; neurogenic locus notch homolog protein 3; Notch gene homolog 3; Notch homolog 3
AW229011; hpbk; N3; Notch3