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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Recombinant protein fragment contains a sequence corresponding to a region within amino acids 1 and 339 of NuMA|
|Storage buffer||PBS, pH 7|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-17293 targets NuMA in ICC, IF, and WB applications and shows reactivity with Human samples.
The MA5-17293 immunogen is recombinant protein fragment contains a sequence corresponding to a region within amino acids 1 and 339 of NuMA.
Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
centrophilin stabilizes mitotic spindle in mitotic cells; nuclear matrix protein-22; SP-H antigen; structural nuclear protein
NMP-22; NMP22; NUMA; NUMA1