|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide, KLH conjugated, corresponding to the N-terminal extracellular domain of human TLX.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.7|
|Contains||0.01% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-24538 detects TLX in human samples.
PA1-24538 has been successfully used in Immunohistochemistry (paraffin) procedures.
PA1-24538 immunogen is a synthetic peptide, KLH conjugated, corresponding to the N-terminal extracellular domain of human TLX. Sequence identity/similarity to mouse: 93/100%.
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Nuclear receptor TLX, a NR2 hepatocyte NF4-like receptor, has been shown to affect anterior brain differentiation, retinal development, and vision. It has been suggested that TLX targets genes for RAR beta2 and Pax2 during retinal development. Homozygous TLX mutant mice are viable at birth but exhibit reduced forebrain development and are more aggressive than wild-type mice. Mice with deleted TLX locus exhibit cerebral hypoplasia, blindness, and extreme aggression (fierce (frc) phenotype). TLX expression has been documented in mouse brain and eye. ESTs have been isolated from normal human brain libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.