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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide region of human NFYA.|
|Storage buffer||PBS with 2% sucrose|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||5-8 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-24431 detects Nuclear Trans. Factor Y alpha isoform 1 in Human samples.
PA1-24431 has been successfully used in Western Blot procedures.
PA1-24431 immunogen corresponds to Polyclonal antibody from rabbits immunized with a synthetic peptide region of human NFYA.
NFYA is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CAAT box DNA-binding protein subunit A; CAAT-box DNA binding protein subunit A; CCAAT-binding transcription factor subunit B; HAP2 CCAAT-binding protein; nuclear transcription factor Y subunit A; nuclear transcription factor Y, alpha; Transcription factor NF-Y, A subunit
CBF-A; CBF-B; HAP2; NF-YA; NFYA