Mimecan induces ectopic bone formation in conjunction with transforming growth factor beta. Mimecan is a small proteoglycan which contains tandem leucine-rich repeats. Mimecan is encoded by the OGN gene, a member of the small leucine-rich proteoglycan (SLRP) family of proteins. Mimecan induces ectopic bone formation in conjunction with transforming growth factor beta (TGF-beta-1 or TGF-beta-2) and may regulate osteoblast differentiation. High expression of mimecan protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants of mimecan. Alternatively spliced transcript variants that encode mimecan have been found.
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Protein Aliases: corneal keratan sulfate proteoglycan; Mimecan; mimecan proteoglycan; OIF; Osteoglycin; osteoglycin/mimecan; Osteoinductive factor
Gene Aliases: OG; OGN; OIF; SLRR3A
UniProt ID: (Human) P20774