In direct ELISAs, this antibody shows approximately 20% cross-reactivity with recombinant human (rh) Olig2 and 50-100% cross-reactivity with rhOlig3.
Reconstitute at 0.5 mg/mL in sterile PBS.
Olig1 promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube. Olig2 is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: basic domain, helix-loop-helix protein, class B, 1; basic domain, helix-loop-helix protein, class B, 6; Basic helix-loop-helix protein class B 1 antibody; bHLHb1; BHLHB6; BHLHB7; bHLHe19; BHLHE20; bHLHe21; BHLHE21Oligodendrocyte transcription factor 3; Class B basic helix-loop-helix protein 1; Class B basic helix-loop-helix protein 6; Class B basic helix-loop-helix protein 7; Class E basic helix-loop-helix protein 19; Class E basic helix-loop-helix protein 20; Class E basic helix-loop-helix protein 21; human protein kinase C-binding protein RACK17; olig1; olig2; olig3; Oligo1; Oligo2; Oligo2 antibody; Oligo3; oligodendrocyte lineage transcription factor 1; Oligodendrocyte transcription factor 1; Oligodendrocyte transcription factor 2; Oligodendrocyte transcription factor 2 antibody; Oligodendrocyte transcription factor 3; oligodendrocyte-specific bHLH transcription factor 1; oligodendrocyte-specific bHLH transcription factor 2; Protein kinase C-binding protein; Protein kinase C-binding protein 2; Protein kinase C-binding protein RACK17
Gene Aliases: BHLHB1; BHLHB6; BHLHB7; BHLHE19; BHLHE20; BHLHE21; OLIG1; OLIG2; OLIG3; OLIGO2; PRKCBP2; RACK17