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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (185 CQKPVRAKSKSAESPS 201) of ORC1L protein.|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1-3 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Origin recognition complex subunit 1 (ORC1L) is a member of the highly conserved six subunits of the Origin Recognition Complex (ORC) which is essential for the initiation of DNA replication in eukaryotic cells. ORC complex binds specifically to origins of replication and serves as a platform for further assembly of additional transcription initiation factors such as Cdc6 and Mcm proteins. ORC1L is the largest encoded protein of the complex. Levels of this protein vary during the cell cycle, which has been shown to be controlled by Ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
HSORC1; ORC1L; origin recognition complex; origin recognition complex subunit 1; origin recognition complex, subunit 1 homolog; PARC1; replication control protein 1; subunit 1 homolog
AA545195; HSORC1; MmORC1; ORC1; ORC1L; PARC1