|Western Blot (WB)||1-3 ug/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (QKTDHVARLTWGGC) corresponding to the C-terminus amino acids of ORC3L|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology.
The origin recognition complex is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: homolog of latheo, Drosophila; IMAGE50150; LAT; LATHEO; ORC3; ORC3L; Origin recognition complex subunit 3; Origin recognition complex subunit Latheo; origin recognition complex, subunit 3; origin recognition complex, subunit 3 (yeast homolog)-like; origin recognition complex, subunit 3 honolog; origin recognition complex, subunit 3-like (yeast); OTTHUMP00000040611; RP3-486L4.1
Gene Aliases: LAT; LATHEO; ORC3; ORC3L
UniProt ID: (Human) Q9UBD5
Entrez Gene ID: (Human) 23595
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