MA5-17022 reacts with ORC6 in human samples.
MA5-17022 has been successfully used in ChIP, immunoprecipitation and Western blot applications.
The MA5-17022 immunogen is ORC6 (hsORC) produced in P3-x63Ag.8.653 cells.
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. ORC6L is a subunit of the ORC complex. It has been shown that ORC6L and and ORC1L are loosely associated with the core complex consisting of ORC2L, 3L, 4L and 5L. Gene silencing studies with small interfering RNA demonstrated that ORC6L plays an essential role in coordinating chromosome replication and segregation with cytokinesis.
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Protein Aliases: ORC 6; ORC6; Origin recognition complex subunit 6
Gene Aliases: ORC6; ORC6L
UniProt ID: (Human) Q9Y5N6
Entrez Gene ID: (Human) 23594