Invitrogen

OX40 Monoclonal Antibody (OX86)

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OX40 Antibody in Flow Cytometry (Flow) — Flow cytometric analysis using a CD134/OX-40 monoclonal antibody (Product # MA1-70087) at a 2.0 µg/10^6 cells dilution.

Product Details

MA1-70087

Applications	Tested Dilution	Publications
Flow Cytometry (Flow)	1 µg/1 million cells	View 3 publications 3 publications

Product Specifications
Species Reactivity	Mouse
Published species	Mouse
Host/Isotype	Rat / IgG1
Class	Monoclonal
Type	Antibody
Clone	OX86
Immunogen	Recombinant mouse OX-40 antigen.
Conjugate	Unconjugated
Form	Liquid
Concentration	1 mg/mL
Purification	Protein G
Storage buffer	PBS
Contains	0.02% sodium azide
Storage conditions	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID	AB_1071227

Product Specific Information

MA1-70087 detects CD134 in mouse samples.

MA1-70087 has been successfully used in flow cytometry procedures.

The MA1-70087 immunogen is recombinant mouse OX-40 antigen.

Target Information

Tumor necrosis factor receptor superfamily, member4, also known as ACT35 or CD134 is a cell surface glycoprotein that was discovered through the production of a monoclonal antibody raised against the HUT-102 cell line. It belongs to the tumor necrosis factor receptor superfamily. CD134 was mapped to 1p36 by fluorescence in situ hybridization. CD134 is the primary receptor for feline immunodeficiency virus. CD134 expression can promote viral binding and renders cells permissive for viral entry, productive infection, and syncytium formation. Stimulating the receptor can improve the response to a powerful virus vector and may be useful in vaccine development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Increase of Frequency and Modulation of Phenotype of Regulatory T Cells by Atorvastatin Is Associated with Decreased Lung Inflammatory Cell Infiltration in a Murine Model of Acute Allergic Asthma.

Frontiers in immunology

Blanquiceth Y,Rodríguez-Perea AL,Tabares Guevara JH,Correa LA,Sánchez MD,Ramírez-Pineda JR,Velilla PA

MA170087 was used in flow cytometry to analyze the in vivo effect of atorvastatin on regulatory T cells and its association with the inflammatory process in a model of allergic asthma

Wed Nov 20 00:00:00 EST 2019

An Immunotherapeutic CD137 Agonist Releases Eomesodermin from ThPOK Repression in CD4 T Cells.

Journal of immunology (Baltimore, Md. : 1950)

Mittal P,Abblett R,Ryan JM,Hagymasi AT,Agyekum-Yamoah A,Svedova J,Reiner SL,St Rose MC,Hanley MP,Vella AT,Adler AJ

MA1-70087 was used in Flow cytometry/Cell sorting to indicate that CD137 costimulation, which is enabled by CD134, programs CD4 T cells to express Eomes through a novel mechanism that selectively releases Eomes from ThPOK repression.

Thu Feb 15 00:00:00 EST 2018

Depleting tumor-specific Tregs at a single site eradicates disseminated tumors.

The Journal of clinical investigation

Marabelle A,Kohrt H,Sagiv-Barfi I,Ajami B,Axtell RC,Zhou G,Rajapaksa R,Green MR,Torchia J,Brody J,Luong R,Rosenblum MD,Steinman L,Levitsky HI,Tse V,Levy R

MA1-70087 was used in Flow Cytometry to demonstrate that intratumoral coinjection of anti-CTLA-4 and anti-OX40 together with CpG depletes tumour-infiltrating regulatory T cells.

Sat Jun 01 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: CD134; OX40 antigen; OX40L receptor; tax-transcriptionally activated glycoprotein 1; Tumor necrosis factor receptor superfamily member 4

Gene Aliases: ACT35; CD134; Ly-70; Ox40; Tnfrsf4; Txgp1; TXGP1L

UniProt ID: (Mouse) P47741

Entrez Gene ID: (Mouse) 22163

Molecular Function: transmembrane signal receptor