|Western Blot (WB)||See 2 publications below|
|Immunofluorescence (IF)||See 2 publications below|
|Tested Species reactivity||Dog, Human, Mouse, Rat|
|Published species reactivity||Rabbit , Rat , Non-human primate Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||GST fusion protein consisting of the C-terminal region (~150aa) of human occludin.|
|Excitation/Emission Profile||View spectra|
|Storage buffer||PBS, pH 7.4, with 50% glycerol, 1% BSA|
|Contains||0.1% sodium azide|
|Storage conditions||4° C|
Occludin is a protein that can exist in a variety of phosphorylated forms, ranging up to approximately 82 kDa. This phosphorylation is thought to be involved in regulating both the localization and the function of occludin. Polyunsaturated fatty acids are known to up-regulate occludin expression, increasing the transendothelial cell resistance and reducing the cellular permeability to large molecules. The level of occludin varies greatly depending on tissue; in brain tissue, occludin is highly and continuously expressed at cell-cell contact sites, whereas non-neural tissues show lower expression and discontinuous distribution.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Occludin; OCLN; phosphatase 1, regulatory subunit 115; tight junction protein occludin
Gene Aliases: AI503564; BLCPMG; Ocl; OCLN; PPP1R115
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