|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant mouse Olig2.|
|Storage buffer||0.2M tris, pH 8, with 0.1M glycine|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The most common primary tumors of the human brain are thought to be of glial cell origin. However, glial cell neoplasms cannot be fully classified by cellular morphology or with conventional markers for astrocytes, oligodendrocytes, or their progenitors. Studies of central nervous system tumorigenesis suggests that novel molecular markers might be found among factors that have roles in glial development. Oligodendrocyte lineage genes (Olig 1 and 2) encode basic helix–loop–helix transcription factors. Human Olig genes are expressed strongly in oligodendroglioma, contrasting absent or low expression in astrocytoma. Therefore, there is diagnostic potential of Olig markers to augment identification of oligodendroglial tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.