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Product Details
17445-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:3,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Oligophrenin 1 Fusion Protein Ag11538 (1-311 aa encoded by BC059393) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.25 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: MGHPPLEFS DCYLDSPDFR ERLKCYEQEL ERTNKFIKDV IKDGNALISA MRNYSSAVQK FSQTLQSFQF DFIGDTLTDD EINIAESFKE FAELLNEVEN ERMMMVHNAS DLLIKPLENF RKEQIGFTKE RKKKFEKDGE RFYSLLDRHL HLSSKKKESQ LQEADLQVDK ERHNFFESSL DYVYQIQEVQ ESKKFNIVEP VLAFLHSLFI SNSLTVELTQ DFLPYKQQLQ LSLQNTRNHF SSTREEMEEL KKRMKEAPQT CKLPGQPTIE GYLYTQEKCV WGHRGIHWVS ISQELLPLVG CEFWAPLLFI DP (1-311 aa encoded by BC059393)
Target Information
Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: mental retardation, X-linked 60; Oligophrenin-1; oligophrenin-1, Rho-GTPase activating protein
Gene Aliases: ARHGAP41; C130037N19Rik; MRX60; OPHN1; OPN1
UniProt ID: (Human) O60890, (Rat) P0CAX5, (Mouse) Q544K7
Entrez Gene ID: (Human) 4983, (Rat) 312108, (Mouse) 94190
Molecular Function:
GTPase-activating protein
substrate-dependent cell migration, cell extension
signal transduction
nervous system development
axon guidance
actin cytoskeleton organization
regulation of endocytosis
positive regulation of GTPase activity
synaptic vesicle endocytosis
regulation of small GTPase mediated signal transduction
regulation of synaptic transmission, glutamatergic
negative regulation of proteasomal protein catabolic process
endocytosis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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