|Western Blot (WB)||1:300-1:2000|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit|
|Immunogen||A synthetic peptide from c-terminal region of human Rhodopsin|
|Storage buffer||whole serum|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
Reconstitute with 100 ul of distilled water.
Centrifuge to remove any insoluble material.
Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal. Abs(max)=495 nm. Rod shaped photoreceptor cells which mediates vision in dim light. Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region. Defects in RHO are the cause of retinitis pigmentosa type 4 (RP4). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP4 inheritance is autosomal dominant. Defects in RHO are also a cause of retinitis pigmentosa autosomal recessive (ARRP). Also, defects in RHO are a cause of autosomal dominant congenital stationary night blindness 1 (CSNBAD1); also known as rhodopsin-related congenital stationary night blindness. Congenital stationary night blindness is a nonprogressive retinal disorder characterized by impaired night vision and ocular symptoms such as myopia, hyperopia, nystagmus and reduced visual acuity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: L opsin; Long Wavelength Sensitive opsin; LWS opsin; MGC138309; MGC138311; OPN2; opsin 2; opsin 2, rod pigment; Opsin-2; Red Opsin; RHO; Rhodopsin; Rhodopsin (retinitis pigmentosa 4, autosomal dominant); Rod Opsin
Gene Aliases: CSNBAD1; Noerg1; OPN2; Ops; RHO; RP4
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