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|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Rat, Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||A synthetic hexadecapeptide (KPDEKYYSSSIWGPTC) (aa345-360) from rat ODC|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-13485 targets Ornithine Decarboxylase in IHC (F) applications and shows reactivity with Human, mouse, and Rat samples.
The MA5-13485 immunogen is a synthetic hexadecapeptide (KPDEKYYSSSIWGPTC) (aa345-360) from rat ODC.
ODC is the initial and rate-limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. The biological activity of ODC is rapidly induced in response to virtually all agents known to promote cell proliferation including hormones, drugs, growth factors, mitogens, and tumor promoters. Reportedly, ODC mRNA levels are elevated in lung carcinomas as well as in colon adenomas and carcinomas. ODC activity in colorectal carcinomas is greater than those in adenomas and normal mucosa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Inflammatory cells are sources of polyamines that induce alveolar macrophage to undergo apoptosis during Pneumocystis pneumonia.
MA5-13485 was used in immunohistochemistry to study the role of inflammatory cell polyamines in alveolar macrophage apoptosis during Pneumocystis pneumonia
|Liao CP,Lasbury ME,Wang SH,Zhang C,Durant PJ,Tschang D,Lee CH||The Journal of eukaryotic microbiology (53 Suppl 1:S134)||2006|
Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless mice.
MA5-13485 was used in western blot to investigate the protective effect of resveratrol against damages caused by short-term ultraviolet B exposure in SKH-1 hairless mice
|Afaq F,Adhami VM,Ahmad N||Toxicology and applied pharmacology (186:28)||2003|
antizyme inhibitor 1; AZI; ODC antizyme inhibitor; ornithine decarboxylase 1-like; ornithine decarboxylase antizyme inhibitor
1700085L02Rik; AZI; AZIA1; AZIN1; OAZI; OAZIN; ODC1L