PA5-16821 targets Osteopontin in IHC (P) applications and shows reactivity with Canine, Human, and Porcine samples.
The PA5-16821 immunogen is a synthetic peptide derived from internal domain of human Osteopontin.
Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation. Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties. Thrombin-cleaved fragments of Osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage and provide a novel substrate for plasmin and cathepsin D.
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Protein Aliases: Bone sialoprotein 1; bone sialoprotein I; bone sialoprotein); early T-lymphocyte activation 1; early T-lymphocyte activation 1); Nephropontin; Osteopontin; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; Secreted phosphoprotein 1; secreted phosphoprotein 1 (osteopontin; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1); secreted phosphoprotein 1 variant 6; secreted phosphoprotein-1 (osteopontin; SPP-1; SPP1/CALPHA1 fusion; Urinary stone protein; Uropontin
Gene Aliases: BNSP; BSPI; ETA-1; OPN; PSEC0156; SPP1
UniProt ID: (Human) P10451
Entrez Gene ID: (Human) 6696