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Invitrogen

Oxytocin/Neurophysin I Recombinant Rabbit Monoclonal Antibody (PSH08-24)

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Oxytocin/Neurophysin I Recombinant Rabbit Monoclonal Antibody (PSH08-24)

Product Details

MA562912

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:2,000-1:5,000
-

Immunohistochemistry (Frozen) (IHC (F))

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

PSH08-24

Immunogen

Recombinant protein within human OXT aa 1-125.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Amount

20 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 0.1% BSA, 40% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3719767

Product Specific Information

Positive Control: Mouse paraventricular nucleus tissue, rat supraoptic nucleus tissue, mouse pituitary tissue, rat pituitary tissue, Mouse pituitary tissue lysate, Rat pituitary tissue lysate.

Tissue Specificity: Tissue enriched (brain).

Subcellular Location: Secreted.

Sequence Similarities: 87% Mouse/Rat.

Predicted band size: 13 kDa

Target Information

Oxytocin is a neuropeptide comprising nine amino acids, synthesized mainly in the hypothalamus and released by the posterior pituitary gland. It functions as a hormone and neuromodulator, facilitating numerous physiological processes such as labor, lactation, and social bonding. The gene encoding oxytocin, located on chromosome 20p13, closely neighbors the gene encoding arginine-vasopressin. Neurophysin I is a carrier protein associated with oxytocin, ensuring its proper storage and release. The gene for Neurophysin I also lies in proximity to the oxytocin gene within the same chromosomal region, indicating co-regulation and functional interdependence. This arrangement reflects a shared evolutionary and functional pathway, highlighting the critical roles of both proteins in neurophysiological functions and their interconnection in the modulation of stress, social behavior, and reproductive functions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: neurophysin 1; neurophysin I; OT-NPI; oxcytocin; oxytocin, prepro- (neurophysin I); oxytocin, prepropeptide; oxytocin-neurophysin I, preproprotein; oxytocin/neurophysin (Oxt) gene, complete gene, complete cds; oxytocin/neurophysin 1 prepropeptide; oxytocin/neurophysin precursor; prepro-oxytocin-neurophysin; pro-OXT; pro-oxytocin/neurophysin; unnamed protein product

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Gene Aliases: OT; OT-NPI; OXT-NPI; Oxy

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UniProt ID: (Human) P01178, (Mouse) P35454, (Rat) P01179

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Entrez Gene ID: (Human) 5020, (Mouse) 18429, (Rat) 25504

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Function(s)
neuropeptide hormone activity neurohypophyseal hormone activity protein binding oxytocin receptor binding protein carrier chaperone
Process(es)
response to amphetamine regulation of heart rate maternal aggressive behavior signal transduction positive regulation of cytosolic calcium ion concentration heart development female pregnancy memory grooming behavior response to sucrose hormone transport positive regulation of norepinephrine secretion response to activity response to food positive regulation of prostaglandin secretion response to estradiol response to retinoic acid response to progesterone response to genistein response to prostaglandin E social behavior intracellular signal transduction negative regulation of urine volume response to cocaine maternal behavior sperm ejaculation eating behavior drinking behavior response to peptide hormone response to ether negative regulation of blood pressure positive regulation of blood pressure positive regulation of ossification positive regulation of female receptivity response to steroid hormone positive regulation of synaptic transmission response to glucocorticoid response to cAMP response to electrical stimulus positive regulation of synapse assembly fetal process involved in parturition male mating behavior positive regulation of penile erection positive regulation of hindgut contraction positive regulation of uterine smooth muscle contraction positive regulation of cold-induced thermogenesis behavioral fear response response to mechanical stimulus response to external biotic stimulus regulation of synaptic plasticity parturition lactation regulation of female receptivity
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