MA5-13854 targets p170 in FACS, WB and ICC/IF applications and shows reactivity with Hamster and Human samples. This antibody does not react with mouse tissue in Western blot applications.
The MA5-13854 immunogen is human and hamster drug-resistant viable cells followed by crude plasma membranes.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
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Protein Aliases: ATP-binding cassette sub-family B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-dependent translocase ABCB1; CD243; colchicin sensitivity; doxorubicin resistance; Multidrug resistance protein 1; Multidrug resistance protein 2; P-glycoprotein 1; P-glycoprotein 2; Phospholipid transporter ABCB1
Gene Aliases: ABC20; ABCB1; CD243; CLCS; GP170; MDR1; P-GP; PGP1; PGP2; PGY1; PGY2