|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Recombinant, full length protein.|
|Storage buffer||ascites diluted in PBS with 1% BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:20|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-26529 detects P Glycoprotein from human samples.
MA1-26529 has been successfully used in immunoprecipitation, immunocytochemistry, immunohistochemistry (paraffin), and Western blot procedures. Positive controls of Drug sensitive parental cell lines and their multidrug-resistant derivatives, human LIver (positive staining detected along luminal surfaces of bile canaliculi) or human colon suggested. A predicted molecular weight of approximately 141 kDa.
The MA1-26529 immunogen is recombinant, full length protein.
Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze/thaw cycles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Molecular profiling in gastric cancer: examining potential targets for chemotherapy.
MA1-26529 was used in immunohistochemistry (paraffin) to use molecular profiling to assess expression of biomarkers of operable gastric adenocarcinoma being treated with epirubicin, cisplatin, and 5-fluorouracil.
|Miura JT,Johnston FM,Thomas J,George B,Eastwood D,Tsai S,Christians KK,Turaga KK,Gamblin TC||Journal of surgical oncology (110:302)||2014|
Epigenetic regulation of MDR1 gene through post-translational histone modifications in prostate cancer.
MA1-26529 was used in immunohistochemistry to study the role of epigenetic histone modification in the reduced MDR1 expression observed in prostate cancer
|Henrique R,Oliveira AI,Costa VL,Baptista T,Martins AT,Morais A,Oliveira J,Jerónimo C||BMC genomics (14:null)||2013|
Putative supramolecular complexes formed by carotenoids and xanthophylls with ascorbic acid to reverse multidrug resistance in cancer cells.
MA1-26529 was used in immunohistochemistry to investigate the interaction of carotenoids and xanthophylls with ascorbic acid and its effect on ABCB1 gene in tumor cells
|Molnár J,Serly J,Pusztai R,Vincze I,Molnár P,Horváth G,Deli J,Maoka T,Zalatnai A,Tokuda H,Nishino H||Anticancer research (32:507)||2012|
Differentiated human colorectal cancer cells protect tumor-initiating cells from irinotecan.
MA1-26529 was used in immunohistochemistry to investigate the association of tumor-initiating potential with irinotecan resistance in human colorectal cancer cells
|Emmink BL,Van Houdt WJ,Vries RG,Hoogwater FJ,Govaert KM,Verheem A,Nijkamp MW,Steller EJ,Jimenez CR,Clevers H,Borel Rinkes IH,Kranenburg O||Gastroenterology (141:269)||2011|
Expression of P-glycoprotein and metallothionein in gastrointestinal stromal tumor and leiomyosarcomas. Clinical implications.
MA1-26529 was used in immunohistochemistry to example the prognostic significance of P-glycoprotein and metallothionein in gastrointestinal stromal tumor and leiomyosarcomas
|Pérez-Gutiérrez S,González-Cámpora R,Amérigo-Navarro J,Beato-Moreno A,Sánchez-León M,Pareja Megía JM,Virizuela-Echaburu JA,López-Beltrán A||Pathology oncology research : POR (13:203)||2007|
Preoperative localization of parathyroid adenomas with technetium-99m methoxyisobutylisonitrile imaging: relationship with P-glycoprotein expression, oxyphilic cell content, and tumoral tissue volume.
MA1-26529 was used in immunohistochemistry to study the effects of P-glycoprotein levels, oxyphilic cell content and tumor volume on the results of technetium 99-MIBI imaging of parathyroid adenomas
|Turgut B,Elagoz S,Erselcan T,Koyuncu A,Dokmetas HS,Hasbek Z,Ozdemir S,Aydin C||Cancer biotherapy and radiopharmaceuticals (21:579)||2006|
Histopathological features and P-glycoprotein expression in retinoblastoma.
MA1-26529 was used in immunohistochemistry to study the histpathology and expression of P-glycoprotein in retinoblastoma
|Filho JP,Correa ZM,Odashiro AN,Coutinho AB,Martins MC,Erwenne CM,Burnier MN||Investigative ophthalmology and visual science (46:3478)||2005|
P-glycoprotein expression is induced in human pancreatic cancer xenografts during treatment with a cell cycle regulator, mimosine.
MA1-26529 was used in immunohistochemistry to study P-glycoprotein expression in human pancreatic cancer xenografts treated with mimosine
|Zalatnai A||Pathology oncology research : POR (11:164)||2005|
Relationship between histopathological features of chemotherapy treated retinoblastoma and P-glycoprotein expression.
MA1-26529 was used in immunohistochemistry to study the expression of P-glycoprotein in retinoblastoma treated with chemotherapy prior to enucleation
|Souza Filho JP,Martins MC,Caissie AL,Torres VL,Fernandes LH,Erwenne CM,Burnier MN||Clinical and experimental ophthalmology (33:279)||2005|
Phase II trial of arsenic trioxide in relapsed and refractory acute myeloid leukemia, secondary leukemia and/or newly diagnosed patients at least 65 years old.
MA1-26529 was used in immunohistochemistry to study the therapeutic potential of arsenic trioxide in relapsed and refractory acute myeloid leukemia
|Parmar S,Rundhaugen LM,Boehlke L,Riley M,Nabhan C,Raji A,Frater JL,Tallman MS||Leukemia research (28:909)||2004|
Reversal effect of PI3-K inhibitor LY294002 on P-glycoprotein-mediated multidrug resistance of human leukemia cell line K562/DNR and gastric cancer cell line SGC7901/ADR.
MA1-26529 was used in western blot to evaluate the efficacy of PI3-K inhibitor LY294002 against the multidrug resistance of human leukemia cell line K562/DNR and gastric cancer cell line SGC7901/ADR
|Zhang Y,Qu XJ,Liu YP,Yang XH,Hou KZ,Teng YE,Zhang JD||Ai zheng = Aizheng = Chinese journal of cancer (28:97)||2009|
Multidrug resistance-related phenotype and apoptosis-related protein expression in ovarian serous carcinomas.
MA1-26529 was used in immunohistochemistry - paraffin section to assess the extent and prognostic significance of MDR-related protein expression in ovarian serous carcinomas and correlate their expression with apoptosis-related proteins
|Yakirevich E,Sabo E,Naroditsky I,Sova Y,Lavie O,Resnick MB||Gynecologic oncology (100:152)||2006|