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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Epidermoid carcinoma cell line A431.|
|Storage buffer||PBS with 1% BSA|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Inhibition Assays (IA)||Assay Dependent|
|Immunofluorescence (IF)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
||Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells.||Müller N,Reinacher-Schick A,Baldus S,van Hengel J,Berx G,Baar A,van Roy F,Schmiegel W,Schwarte-Waldhoff I||Oncogene (21:6049)||2002|
|Human||Not Cited||The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts.||Braga VM,Machesky LM,Hall A,Hotchin NA||The Journal of cell biology (137:1421)||1997|
|Human||Not Cited||Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells.||Müller N,Reinacher-Schick A,Baldus S,van Hengel J,Berx G,Baar A,van Roy F,Schmiegel W,Schwarte-Waldhoff I||Oncogene (21:6049)||2002|
cadherin 3, type 1, P-cadherin (placental); cadherin-3; calcium-dependent adhesion protein; calcium-dependent adhesion protein, placental; CDHP; HJMD; PCAD; placental
CDH3; CDHP; HJMD; PCAD