|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Epidermoid carcinoma cell line A431.|
|Storage buffer||PBS with 1% BSA|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Inhibition Assays (IA)||Assay Dependent|
|Immunofluorescence (IF)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Not Applicable||Not Cited||
Extracellular cleavage and shedding of P-cadherin: a mechanism underlying the invasive behaviour of breast cancer cells.
13-5800 was used in blocking or activating experiment to study the invasive behavior of P-cadherin expressing breast tumors
|Ribeiro AS,Albergaria A,Sousa B,Correia AL,Bracke M,Seruca R,Schmitt FC,Paredes J||Oncogene (29:392)||2010|
Increased shedding of soluble fragments of P-cadherin in nipple aspirate fluids from women with breast cancer.
13-5800 was used in immunocytochemistry, immunohistochemistry - paraffin section, immunoprecipitation, and western blot to measure the soluble fragment of P-cadherin in milk, nipple aspirate fluid, and plasma from breast cancer patients
|Mannello F,Tonti GA,Medda V,Pederzoli A,Sauter ER||Cancer science (99:2160)||2008|
Cadherin switching dictates the biology of transitional cell carcinoma of the bladder: ex vivo and in vitro studies.
13-5800 was used in blocking assay to investigate the role of P-cadherin in bladder transitional cell carcinomas.
|Bryan RT,Atherfold PA,Yeo Y,Jones LJ,Harrison RF,Wallace DM,Jankowski JA||The Journal of pathology (215:184)||2008|
The fate of E- and P-cadherin during the early stages of apoptosis.
13-5800 was used in western blot to investigate cisplatin-induced apoptosis in human embryo retinoblasts.
|Schmeiser K,Grand RJ||Cell death and differentiation (6:377)||1999|
||Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells.||Müller N,Reinacher-Schick A,Baldus S,van Hengel J,Berx G,Baar A,van Roy F,Schmiegel W,Schwarte-Waldhoff I||Oncogene (21:6049)||2002|
|Human||Not Cited||The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts.||Braga VM,Machesky LM,Hall A,Hotchin NA||The Journal of cell biology (137:1421)||1997|
|Human||Not Cited||Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells.||Müller N,Reinacher-Schick A,Baldus S,van Hengel J,Berx G,Baar A,van Roy F,Schmiegel W,Schwarte-Waldhoff I||Oncogene (21:6049)||2002|