This antibody has specificity for Mouse CDH3/CDHP.
P-cadherin, also known as Cadherin-3, is a Type 1 cadherin protein that belongs to the cadherin superfamily. Type 1 cadherins are single-pass transmembrane proteins that have 5 extracellular cadherin repeats and an intracellular domain that binds p120-catenin and beta-catenin. Cadherins are calcium-dependent cell-cell adhesion glycoproteins responsible for a range of processes including development, wound healing, cell-cell signaling, cell growth and differentiation. P-cadherin is expressed in human fetal structures, and in adult tissues such as the basal layer of the epidermis, breast, prostate, ovary, cervix, hair follicle, and corneal endothelium. P-cadherin expression has also been reported on embryonic stem cells, and stem cells of the normal mammary gland, and hair follicle. Overexpression of P-cadherin has been associated with poor prognosis in breast, prostate, ovary, colon, and stomach carcinomas. Mutations in CDH3 are associated with congential hypotrichosis with juvenile macular dystrophy.
Protein Aliases: CADH3; Cadherin-3; P-cadherin; Placental cadherin; Placental-cadherin; RPE-specific cadherin
Gene Aliases: AI385538; Cadp; Cdh3; Cdhp; P-cadherin; Pcad
UniProt ID: (Mouse) P10287
Entrez Gene ID: (Mouse) 12560
Molecular Function: cadherin