This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
32-4000 has successfully been used in western blot to detect P-cadherin in MDCK cell lysates.
P-cadherin, also known as Cadherin-3, is a Type 1 cadherin protein that belongs to the cadherin superfamily. Type 1 cadherins are single-pass transmembrane proteins that have 5 extracellular cadherin repeats and an intracellular domain that binds p120-catenin and beta-catenin. Cadherins are calcium-dependent cell-cell adhesion glycoproteins responsible for a range of processes including development, wound healing, cell-cell signaling, cell growth and differentiation. P-cadherin is expressed in human fetal structures, and in adult tissues such as the basal layer of the epidermis, breast, prostate, ovary, cervix, hair follicle, and corneal endothelium. P-cadherin expression has also been reported on embryonic stem cells, and stem cells of the normal mammary gland, and hair follicle. Overexpression of P-cadherin has been associated with poor prognosis in breast, prostate, ovary, colon, and stomach carcinomas. Mutations in CDH3 are associated with congential hypotrichosis with juvenile macular dystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cadherin 15, M-cadherin (myotubule); cadherin 3, type 1, P-cadherin (placental); Cadherin-3; calcium-dependent adhesion protein; calcium-dependent adhesion protein, placental; CDHP; HJMD; P-cadherin; PCAD; placental; Placental cadherin
Gene Aliases: CDH15; CDH3; CDHP; HJMD; PCAD
UniProt ID: (Human) P22223
Molecular Function: cadherin