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|Tested species reactivity||Dog , Human , Mouse , Rat|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Mouse recombinant p27Kip1 protein.|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay-Dependent|
|Immunofluorescence (IF)||Assay Dependent|
|Immunohistochemistry (IHC)||Assay Dependent|
|Western Blot (WB)||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
p27Kip1 is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation.
AHZ0452 was used in western blot to study kinases involved in H2AX phosphorylation in irradiated human keratinocytes
|Benzina S,Pitaval A,Lemercier C,Lustremant C,Frouin V,Wu N,Papine A,Soussaline F,Romeo PH,Gidrol X||Cellular and molecular life sciences : CMLS (72:3559)||2015|
p27, CDKN4, Cdki1b, Kip1, MEN4, KIP1, P27KIP1, AA408329, p27Kip1, MEN1B, AI843786
Cyclin-dependent kinase inhibitor 1B (p27 Kip1), Cyclin-dependent kinase inhibitor 1B (p27, Kip1), cyclin-dependent kinase inhibitor 1B, cyclin-dependent kinase inhibitor p27, cyclin-dependent kinase inhibitor p27/Kip1, putative cyclin-dependent kinase inhibitor p27, CDKN1B, CDN1B, Cyclin-dependent kinase inhibitor 1B, KIP1