This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: LKEYILVEEA KLSKIKSWAN KMEALTSKSA ADAEGYLAHP VNAYKLVKRL NTDWPALEDL VLQDSAAGFI ANLSVQRQFF PTDEDEIGAA KALMRLQDTY RLDPGTISRG ELPGTKYQAM LSVDDCFGM
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 91%.
Binds to an epitope located within the peptide sequence NTDWPALEDLVLQDS as determined by overlapping synthetic peptides.
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase); 2-oxoglutarate-4-dioxygenase subunit alpha-2; 4-PH alpha 2; 4-PH alpha-2; alpha polypeptide II; C-P4Halpha(II); collagen prolyl 4-hydroxylase alpha(II); procollagen-proline; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II; Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2; prolyl 4-hydr; Prolyl 4-hydroxylase subunit alpha-2; prolyl 4-hydroxylase, alpha polypeptide II
Gene Aliases: P4HA2; UNQ290/PRO330
UniProt ID: (Human) O15460
Entrez Gene ID: (Human) 8974