PA1-1742 detects ADAMTS5 in human samples.
PA1-1742 has been successfully used in Western blot procedures. In Western blot analysis of JJ012 cells this antibody detects a ~64 kDa protein representing ADAMTS5.
The PA1-1742 immunogen is a synthetic peptide corresponding to residues C I(442) L T S I D A S K P(451) of human ADAMTS5.
ADAMTS proteases are secreted enzymes containing a prometalloprotease domain of the reprolysin type. The ADAMTS proteases function in processing of procollagens and von Willebrand factor as well as catabolism of aggrecan, versican and brevican. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: A disintegrin and metalloproteinase with thrombospondin motifs 11; A disintegrin and metalloproteinase with thrombospondin motifs 5; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2); ADAM-TS 11; ADAM-TS 5; ADAM-TS5; ADMP-2; Aggrecanase-2
Gene Aliases: ADAM-TS 11; ADAM-TS 5; ADAM-TS5; ADAMTS-11; ADAMTS-5; ADAMTS11; ADAMTS5; ADMP-2; ADMP2
UniProt ID: (Human) Q9UNA0
Entrez Gene ID: (Human) 11096