|Western Blot (WB)||1 µg/mL|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues C P(503) E V V N D E S S L V R H R W K(518) of human BACE2.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 1mg/mL BSA|
|Contains||0.05% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA1-1754 detects human beta-secretase 2 (BACE2). This product is a remanufactured version of PA1-754 produced in new rabbits.
PA1-1754 has been successfully used in Western blot procedures. By Western blot this antibody detects an ~58 kDa protein representing BACE2 in endogenous and overexpressing HEK-293 cells. PA1-1754 also detects two unidentified bands at ~61 kDa and ~80 kDa.
The PA1-1754 immunogen is a synthetic peptide corresponding to residues C P(503) E V V N D E S S L V R H R W K(518) of human BACE2. This sequence is completely conserved in mouse. The PA1-1754 immunizing peptide (Cat. # PEP-167) is available for use in neutralization and control experiments.
BACE2 or Beta Secretase 2 is responsible for the proteolytic processing of the amyloid precursor protein (APP). BACE2 cleaves APP between residues 690 and 691. This cleavage leads to the generation and extracellular release of beta-cleaved soluble APP. BACE2 is also know to cleave APP between residues 671 and 672. Accumulation of APP is a signature of Alzheimer disease and frequent complication of adult Down syndrome patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 56 kDa aspartic-like protease; Asp 1; ASP1; Aspartic-like protease 56 kDa; Aspartyl protease 1; BACE2; Beta-secretase 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; Beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; Beta-Site APP-Cleaving Enzyme 2; Down region aspartic pr; Down region aspartic protease; Down syndrome region aspartic protease; DRAP; memapsin 1; Memapsin-1; Membrane-associated aspartic protease 1; Theta-secretase; transmembrane aspartic proteinase Asp1
Gene Aliases: AEPLC; ALP56; ASP1; ASP21; BACE2; BAE2; CDA13; CEAP1; DRAP; UNQ418/PRO852
UniProt ID: (Human) Q9Y5Z0
Entrez Gene ID: (Human) 25825
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