Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
PA1-28286 detects beta Synuclein from human samples.
PA1-28286 has been successfully used in Western blot applications.
The PA1-28286 immunogen is: Fusion protein, corresponding to amino acids 1-134 of Human beta Synuclein.
Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates they are encoded by three different genes. Synucleins have been specifically implemented in three major diseases: Alzheimer's (AD), Parkinson's PD) and breast cancer. In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha synuclein accumulates in Lewy bodies. An allele of alpha synuclein has been linked to many familial cases of PD. In breast cancer increased expression of gamma synuclein correlates with the disease progression. Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Beta-synuclein
Gene Aliases: SNCB
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