TRPM2 belongs to the ion transport protein family which includes Sodium, Potassium, Calcium ion channels. This family is characterized by proteins possessing 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. TRPM2 is activated by oxidative stress and confers susceptibility to cell death. Further, TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Several alternatively spliced transcript variants of the TRPM2 gene have been described, but their full-length nature is not known.
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Protein Aliases: EC 184.108.40.206; Long transient receptor potential chan; Long transient receptor potential channel 2; LTrpC-2; null; Transient receptor potential cation channel subfamily M member 2; Transient receptor potential channel 7; transient receptor potential melastatin family 2; transient receptor protein 7; TrpC7
Gene Aliases: 9830168K16Rik; C79133; LTRPC2; Trp7; TRPC7; Trpm2; Trpm2-predicted; Trrp7