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Synthetic Peptide: C P(503) E V V N D E S S L V R H R W K(518)
Antigen affinity chromatography
PBS with 1mg/mL BSA
0.05% sodium azide
-20° C, Avoid Freeze/Thaw Cycles
Product Specific Information
PA1-754 detects human and mouse beta-secretase 2 (BACE2) from transfected cells. This product has recently been remanufactured in new rabbits as Cat. # PA1-1754.
PA1-754 has been successfully used in Western blot and ICC/IF procedures. By Western blot this antibody detects an ~58 kDa protein representing BACE2 from SY-SY5Y cells overexpressing the human gene.
The PA1-754 immunogen is amino acid residues 503-518 from human BACE2. This sequence is completely conserved in mouse. The PA1-754 immunizing peptide (Cat. # PEP-167) is available for use in neutralization and control experiments.
BACE2 or Beta Secretase 2 is responsible for the proteolytic processing of the amyloid precursor protein (APP). BACE2 cleaves APP between residues 690 and 691. This cleavage leads to the generation and extracellular release of beta-cleaved soluble APP. BACE2 is also know to cleave APP between residues 671 and 672. Accumulation of APP is a signature of Alzheimer disease and frequent complication of adult Down syndrome patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Protein Aliases: 56 kDa aspartic-like protease; Asp 1; ASP1; Aspartic-like protease 56 kDa; Aspartyl protease 1; BACE2; Beta-secretase 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; Beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; Beta-Site APP-Cleaving Enzyme 2; Down region aspartic pr; Down region aspartic protease; Down syndrome region aspartic protease; DRAP; memapsin 1; Memapsin-1; Membrane-associated aspartic protease 1; Theta-secretase; transmembrane aspartic proteinase Asp1