PA1-9527 detects Hemoglobin alpha in human samples.
PA1-9527 has been successfully used in Western blot and ELISA procedures. By Western blot, PA1-9527 detects a 15 kDa protein representing Hemoglobin alpha.
PA1-9527 immunogen is a synthetic peptide based on the human hemoglobin alpha protein.
The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: alpha one globin; alpha-2 globin chain; Alpha-globin; ALPHA-GLOBIN GENE; delta globin; hemoglobin alpha 1 globin chain; Hemoglobin alpha chain; Hemoglobin subunit alpha; hemoglobin, alpha 1
Gene Aliases: HBA-T3; HBA1; HBA2; HBH
UniProt ID: (Human) P69905
Entrez Gene ID: (Human) 3039
Molecular Function: transfer/carrier protein