IHC (P) analysis shows positive staining of GPR12 in human kidney tissue.
The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. GPR12 is an orphan G-protein-coupled receptor which constitutively activates the Gs protein and increases intracellular cAMP. GPR12 can also be activated by sphingosylphosphorylcholine to promote various cellular functions which include proliferation, neurite outgrowth, cell survival and differentiation.
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Protein Aliases: G protein-coupled receptor 12; G-protein coupled receptor 12; GPCR12; GPR12; protein phosphatase 1, regulatory subunit 84
Gene Aliases: GPCR12; GPCR21; GPR12; PPP1R84
UniProt ID: (Human) P47775
Entrez Gene ID: (Human) 2835