IHC (P) analysis shows positive staining of GPR31 in human enteric ganglion.
The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding leads to activation of MAPK and NF-kappa-B pathways.
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Protein Aliases: 12-(S)-HETE acid receptor; 12-(S)-HETE receptor; 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (HETE) receptor; 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; bA517H2.2 (G protein-coupled receptor 31); G-protein coupled receptor 31; hydroxyeicosatetraenoic (HETE) acid receptor 1; probable G-protein coupled receptor 31; TCP10C
Gene Aliases: 12-HETER; GPR31; HETER; HETER1
UniProt ID: (Human) O00270
Entrez Gene ID: (Human) 2853