PA3-981 detects c-Myc tagged proteins.
PA3-981 has been successfully used in immunofluorescence, immunoprecipitation, and Western blot procedures. By Western blot it detects a ~41 kDa protein representing c-Myc.
The PA3-981 immunogen is a synthetic peptide corresponding to residues M E Q K L I S E E D L G C of human c-Myc.
The c-myc oncogene (p62 c-myc) is involved in the control of normal cellular proliferation and differentiation. In addition, deregulated expression of c-Myc induces apoptosis in different cell types, with c-myc requiring p53 for apoptosis in many cell types. This fact indicates heterogeneous mechanisms for c-myc-induced apoptosis.
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Protein Aliases: avian myelocytomatosis viral oncogene homolog; bHLHe39; c Myc; Cellular myelocytomatosis oncogene; Class E basic helix-loop-helix protein 39; Myc proto oncogene protein; Myc proto-oncogene protein; myc-related translation/localization regulatory factor; Myc2; Niard; Nird; Proto-oncogene c-Myc; Transcription factor p64; v myc avian myelocytomatosis viral oncogene hom; v-myc myelocytomatosis viral oncogene homolog
Gene Aliases: BHLHE39; c-Myc; MRTL; MYC; MYCC
UniProt ID: (Human) P01106
Entrez Gene ID: (Human) 4609