Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during trancription initiation such as preinitiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: RNA polymerase I-specific TBP-associated factor 63 kDa; RNA polymerase I-specific TBP-associated factor 68 kDa; SL1, 63kD subunit; TAFI63; TAFI68; TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kD; TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa; TATA box binding protein associated factor 1B; TATA box-binding protein-associated factor 1B; TATA box-binding protein-associated factor RNA polymerase I subunit B; TATA-box binding protein associated factor, RNA polymerase I, B; TBP-associated factor 1B; TBP-associated factor RNA polymerase I 68; transcription factor TAFI68; Transcription initiation factor SL1/TIF-IB subunit B
Gene Aliases: 4930408G01Rik; A230108M10Rik; MGC:9349; p63; RAF1B; RAFI63; SL1; TAF1B; TAFI63; TAFI68; Tafi86