Sequence of this protein is as follows: MSNMEKHLFN LKFAAKELSR SAKKCDKEEK AEKAKIKKAI QKGNMEVARI HAENAIRQKN QAVNFLRMSA RVDAVAARVQ TAVTMGKVTK SMAGVVKSMD ATLKTMNLEK ISALMDKFEH QFETLDVQTQ QMEDTMSSTT TLTTPQNQVD MLLQEMADEA GLDLNMELPQ GQTGSVGTSV ASAEQDELSQ RLARLRDQV
CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 ).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Charged multivesicular body protein 1b; Charged multivesicular body protein 1b-1; CHMP1.5; CHMP1b; CHMP1b-1; chromatin modifying protein 1B; Chromatin-modifying protein 1b; Chromatin-modifying protein 1b-1; vacuolar protein sorting 46-2; Vacuolar protein sorting-associated protein 46-2; Vps46-2
Gene Aliases: 2810405I11Rik; C10orf2; C18-ORF2; C18orf2; CHMP1.5; CHMP1B; Chmp1b1; hVps46-2; Vps46-2; Vps46B
Molecular Function: membrane traffic protein