Immunogen sequence: KTKEGEGSQQ SRGRKYGSNV NRIKNLFMQM GMEPNENAAV IAKTRGKGGH SSPQRRMKPK EFLEKTDGSV VKLESSVSER IS
Neurabin I is a brain-specific protein which contains an F-actin binding domain, a PDZ domain, a transmembrane-protein-interacting-domain, and a coiled-coil region. As its structure suggests, neurabin I is a promiscuous protein binding to F-actin, protein phosphatase 1, TGN38, and p70 S6 kinase. Found exclusively in brain, this protein is highly concentrated in the synapse and has also been shown to be enriched in the lamellipodia of the growth cone during neuronal development. Neurabin I appears to be a bridging protein by targeting other proteins to the synapse or by linking membrane proteins to the actin cytoskeleton.
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Protein Aliases: Neurabin-1; Neurabin-I; Neural tissue-specific F-actin-binding protein I; Protein phosphatase 1 regulatory subunit 9A; protein phosphatase 1, regulatory (inhibitor) subunit 9A; protein phosphatase 1, regulatory subunit 9A
Gene Aliases: KIAA1222; Neurabin-I; NRB1; NRBI; PPP1R9A
UniProt ID: (Human) Q9ULJ8
Entrez Gene ID: (Human) 55607