CYP1A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. CYP1A1 gene has been associated with lung cancer risk.
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Protein Aliases: aromatic compound inducible; aryl hydrocarbon hydroxylase; CYPIA1; cytochrome P1-450, dioxin-inducible; Cytochrome P450 1A1; cytochrome P450 family 1 subfamily a polypeptide 2; Cytochrome P450 form 6; cytochrome P450 subfamily I, polypeptide 1; cytochrome P450, 1a1, aromatic compound inducible; cytochrome P450, family 1, subfamily A, polypeptide 1; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1; Cytochrome P450-C; Cytochrome P450-P1; flavoprotein-linked monooxygenase; P450 form 6; P450-C; P450-P1; xenobiotic monooxygenase
Gene Aliases: AHH; AHRR; CP11; CYP1; Cyp1a-1; CYP1A1; Cyp1a2; CYPIA1; P1-450; P450-1; P450-C; P450DX