This antibody is predicted to react with bovine, canine, human and rat based on sequence homology.
The protein encoded by this gene is a member of the tripartite motif family, also called the 'RING-B-box-coiled-coil' subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: brain expressed ring finger; Brain-expressed RING finger protein; RING finger protein 22; RING finger protein 97; RING finger protein HAC1; tripartite motif protein 3; tripartite motif protein TRIM3; tripartite motif-containing 3; Tripartite motif-containing protein 3
Gene Aliases: BERP; BERP1; HAC1; RNF22; RNF97; TRIM3
Molecular Function: ubiquitin-protein ligase