This antibody is predicted to react with bovine and canine based on sequence homology.
This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle.
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Protein Aliases: E3 ubiquitin-protein ligase TRIM63; FLJ32380; Iris RING finger protein; MURF 1; MuRF-1; muscle specific ring finger protein 2; Muscle-specific RING finger protein 1; OTTHUMP00000008701; RING finger protein 28; RING-type E3 ubiquitin transferase TRIM63; RNF 28; Striated muscle RING zinc finger protein; TRIM 63; tripartite motif containing 63, E3 ubiquitin protein ligase; Tripartite motif-containing protein 63
Gene Aliases: IRF; MURF1; MURF2; RNF28; SMRZ; TRIM63
UniProt ID: (Human) Q969Q1
Entrez Gene ID: (Human) 84676
Molecular Function: ubiquitin-protein ligase