This antibody is predicted to react with bovine, canine, mouse, porcine and rat based on sequence homology.
This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized.
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Protein Aliases: cytosolic phosphoenolpyruvate carboxykinase 1; HGNC:8724; MGC22652; PCK1; PEP carboxykinase; PEPCK-C; PEPCK1; PEPCKC; phosphoenolpyruvate carboxykinase 1 (soluble); phosphoenolpyruvate carboxykinase, cytosolic; Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; phosphoenolpyruvate carboxylase; phosphopyruvate carboxylase
Gene Aliases: PCK1; PEPCK-C; PEPCK1; PEPCKC
UniProt ID: (Human) P35558
Entrez Gene ID: (Human) 5105