This antibody is predicted to react with mouse and rat based on sequence homology.
This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment domains and six leucine-rich repeats by recognizing the muramyl dipeptide derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome.
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Protein Aliases: ACUG; BLAU; CARD15; caspase recruitment domain family, member 15; caspase recruitment domain protein 15; Caspase recruitment domain-containing protein 15; CD; IBD1; Inflammatory bowel disease protein 1; LRR-containing protein; NLR family, CARD domain containing 2; NOD-like receptor C2; NOD2; NOD2 protein; NOD2B; nucleotide-binding oligomerization domain 2; nucleotide-binding oligomerization domain containing 2; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2; Nucleotide-binding oligomerization domain-containing protein 2; PSORAS1
Gene Aliases: ACUG; BLAU; CARD15; CD; CLR16.3; IBD1; NLRC2; NOD2; NOD2B; PSORAS1
UniProt ID: (Human) Q9HC29
Entrez Gene ID: (Human) 64127