This gene encodes a multifunctional protein. It has two enzymatically active domains with catalytic activities - peptidylglycine alpha-hydroxylating monooxygenase and peptidyl-alpha-hydroxyglycine alpha-amidating lyase . These catalytic domains work sequentially to catalyze neuroendocrine peptides to active alpha-amidated products. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene but some of their full length sequences are not yet known.
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Protein Aliases: PAL; PAM; pancreatic peptidylglycine alpha-amidating monooxygenase; peptidyl alpha-amidating enzyme; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase; Peptidyl-glycine alpha-amidating monooxygenase; Peptidylamidoglycolate lyase; peptidylglycine 2-hydroxylase; peptidylglycine alpha-amidating monooxygenase; Peptidylglycine alpha-hydroxylating monooxygenase; PHM
Gene Aliases: PAL; PAM; PHM
UniProt ID: (Human) P19021
Entrez Gene ID: (Human) 5066