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PA5-19420 targets KMT7 / SETD7/ SET7/9 in WB applications and shows reactivity with Yeast samples.
The PA5-19420 immunogen is recombinant full length protein of S. pombe SET7 /SET9.
PA5-19420 detects KMT7 / SETD7/ SET7/9 which has a predicted molecular weight of approximately 55 kDa.
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DNA-directed RNA polymerase II subunit RPB1; DNA-directed RNA polymerase III largest subunit; FLJ21193; OTTHUMP00000220049; RNA polymerase II subunit 1; RNA polymerase II subunit B220
Gene Aliases: D2150; RPB1; RPB220; RPO21; SUA8; YDL140C
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